ACADL and paroxysmal nocturnal hemoglobinuria: In total agreement with our hypothesis linking perturbations in acyl CoA metabolism to PNH, unsupervised quantitative clustering analysis, using the heatmap (Fig 1b), and the Pearson r correlation analysis revealed (with p Values of association <10e-25) that PNH patients share a significant degree of correlation to ACADS, ACADM, ACADL and ETFDH insufficiencies, as well as to ACSL1 and SCD (Table 4).