Knowing that impaired apoptosis of synovial fibroblasts is key in RA pathogenesis (Baier et al. 2003), and that activating transcription factor-6 (ATF-6) and C/EBP homologous protein (CHOP) are essential for the adaptive repair mechanism (Rahmati et al. 2018), make this mechanistic pathway attractive for the validation of the formulation success in AA. The gene discussed is ATF6; the disease is rheumatoid arthritis.