In another study, extracellular vesicle Long RNA (NFKBIA, NDUFB10, SLC7A7, ARPC5, SEPTIN9, HMGN1, H4C2, and Lnc-PLA2G1B-2) were regarded as signature of early NSCLC (diameter < 2 cm), and extracellular vesicle Long RNA can be used as a supplement to LDCT as a noninvasive biomarker for screening early NSCLC [32]. This evidence concerns the gene SEPTIN9 and non-small cell lung carcinoma.