This makes circulating ncRNA as markers of disease diagnosis feasible and convenient for clinical detection.At present, a large number of studies have shown that compared with traditional biomarkers such as carcinoembryonic antigen (CEA) and neuron-specific enolase(NSE), circulating ncRNAs including miR-21, HOTAIR and miR-25 have better sensitivity and specificity for the diagnosis of NSCLC, which also makes them have a very attractive clinical application potential [14–16]. Here, ENO2 is linked to non-small cell lung carcinoma.