MEG3 and non-small cell lung carcinoma: In the venous blood of Chinese patients with NSCLC, ANRIL, MEG3, POLR2E, and HOTTIP and their single-nucleotide polymorphisms were analyzed, and the results showed that ANRIL rs1333049 was associated with severe gastrointestinal toxicity, MEG3 rs116907618 was associated with severe gastrointestinal toxicity, and the three-factor interaction model of the POLR2E–rs3787016-HOTTIP–rs3807598-chemotherapy regimen was the best predictive model for hematological toxicity [168].