MHCII+ CD163− TAMs express lower levels of melanoma genes (LYZ, S100A8), cytokines and chemokines genes (IL1B, IL8, IL10, CCL2 and CCL5), of antigen presentation related genes (CD80 and CD274), and of genes implicated in angiogenesis, invasion and epithelial-mesenchymal transition (CSF1, MMP14 and VEGFA). The gene discussed is CD274; the disease is melanoma.