CD8A and neoplasm: To further investigate whether the elevated αKG in tumor cells might cause differences in anti‐tumor immune responses, we collected activated CD8+ T cells and co‐cultured them with αKG‐treated Renca cells at a 2:1, 3:1, and 5:1 ratio for 24 h, respectively, and the results showed that CD8+ T cells exerted dramatically stronger cytotoxicity against αKG‐treated Renca cells compared to the control group at any co‐incubation rates (Figure 6C; Figure S4A, Supporting Information).