The findings of this work raise the intriguing possibility that aberrant upregulation of adipose Mettl3, Mettl14, and m6A methylation of Adrb2, Adrb3, Atgl, and Cgi‐58 transcripts, and translational suppression of these transcripts may explain adipose catecholamine resistance and lipolysis suppression in obesity. This evidence concerns the gene PNPLA2 and Obesity.