Collectively, these results suggest that upregulation of adipocyte Mettl3, Mettl14, and m6A methylation of Atgl, Cgi‐58, Adrb2, and Adrb3 transcripts causes, at least in part, adipose catecholamine resistance, lipolysis suppression, adipose expansion, and metabolic disorders in obesity. Here, ADRB2 is linked to obesity due to melanocortin 4 receptor deficiency.