Adrb2, Atgl, and Cgi‐58 mRNA levels in iWAT were comparable between chow and HFD fed mice (Figure 7C), raising the possibility that Adrb2, Atgl, and Cgi‐58 proteins are downregulated in obesity by a posttranscriptional mechanism (e.g., m6A methylation). This evidence concerns the gene PNPLA2 and obesity disorder.