Unlike Mettl14Δfat mice which are resistant to HFD‐induced obesity, mice with BAT‐specific deletion of Mettl3 are prone to diet‐induced obesity.[18] These opposite phenotypes further support the notion that increases in β adrenergic signaling and lipolysis in WAT, which are observed in Mettl14Δfat mice but not in Mettl3‐deficient mice, mediate protection of Mettl14Δfat mice against obesity. Here, METTL3 is linked to obesity due to melanocortin 4 receptor deficiency.