INS and Insulin resistance: Pancreatic β cell‐specific deletion of Mettl14 impairs insulin secretion and promotes diabetes.[15] Liver‐specific deletion of Mettl3 attenuates HFD‐induced insulin resistance and liver steatosis.[16] These observations indicate that the Mettl14/Mettl3/m6A system in metabolic tissues plays an important role in the maintenance of metabolic homeostasis.