Adipocyte‐specific ablation of adipose triglyceride lipase (ATGL), which catalyzes the first reaction of lipolysis and is downregulated in obesity, results in excessive WAT expansion.[1] Conversely, adipocyte‐specific overexpression of ATGL, or ablation of ATGL suppressor G0S2, protects against obesity and obesity‐associated metabolic disorders.[2] These observations raise the possibility that ATGL downregulation and lipolysis suppression may play an important role in obesity development. Here, PNPLA2 is linked to obesity due to melanocortin 4 receptor deficiency.