Many ribosomopathies, such as some cases of Diamond Blackfan Anaemia (most commonly mutated gene encodes RPS19 (eS19)) and 5q syndrome (RPS14 (uS11)), can result from defects in SSU production making it important to understand how SSU production defects activate p53 through the 5S RNP (10,13). The gene discussed is TP53; the disease is Diamond-Blackfan anemia.