However, administration of antioxidant reagents NAC or MnTBAP had no clearly demonstrable effects, suggesting enhanced function of STAT3–/– T cells to cause GVHD in vivo (Supplemental Figure 12), although previous studies showed that antioxidants augmented acute GVHD induced by WT T cells (20). The gene discussed is STAT3; the disease is acute graft versus host disease.