Top genes in the initial comparisons were largely derived from tumors and included genes associated with HR genetics such as FGFR3 and MYC, which are linked to shorter PFS (17, 18), and genes associated with a differentiated PC phenotype (e.g., SLAMF7, IRF4) or standard-risk genetics (cyclin D1 [CCND1]), which are linked to longer PFS (Supplemental Figure 24). The gene discussed is IRF4; the disease is pachyonychia congenita.