Analysis of single agonistic antibodies (and combinations) revealed that T cell entry of KMS-18 clusters was dependent on the degree and nature of stimulation and was higher for α-CD3/CD28/CD2–mediated stimulation relative to α-CD3/CD28 (Figure 2F), suggesting a potential role for CD2 in regulating T cell entry into MM clusters. This evidence concerns the gene CD28 and Miyoshi myopathy.