Thus, in the present study, we utilized the cecal ligation and perforation (CLP) murine model, a classic model of SI‐AKI, to assess whether the progression of sepsis‐induced renal injury is epigenetically regulated by PRMT1 through the TGF‐β1/Smad3 and IL‐6/STAT3 pathways. This evidence concerns the gene SMAD3 and acute kidney injury.