Compared with the mice from the sham group, the expression levels of COX‐2, IL‐6, sIL‐6R, and p‐STAT3 were significantly increased after CLP operation, whereas AMI‐1 injection downregulated the expression levels of these proteins in both the sham and CLP groups (P < 0.01), suggesting that inhibition of PRMT1 stopped the inflammation induced by sepsis by blocking activation of STAT3 (Fig. 6B). This evidence concerns the gene IL6R and Sepsis.