Being from a sickle endemic zone and belonging to a most susceptible community of central India, at that time sickle cell disease (SCD) versus other hemolytic conditions were thought of, and most workups were done, but as per old medical records and reports retrieved, evidence of hemolysis along with hematuria (but no documented hemoglobinuria) was there, but all workups for SCD, glucose-6-phosphate dehydrogenase (G6PD) deficiency, HUS (Hemolytic Uremic Syndrome), autoimmune disease, and other likely causes of hemolytic anaemia were negative. This evidence concerns the gene G6PD and hemolytic-uremic syndrome.