Increased NLR values in NAFLD patients are brought on by inflammation that develops as a result of systemic lipotoxicity resulting from lipid metabolites, insulin resistance, the release of proinflammatory cytokines including IL-6 and tumor necrosis factor (TNF)-α, as well as oxidative stress and adipokines [21]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.