Besides, target genes of differential miRNAs between N-RA and P-RA group included phosphatase, orphan 2 (PHOSPHO2), GBA, TNF, CD79b molecule (CD79B), CD4, calcium and integrin binding family member 2 (CIB2), progestin and adipoQ receptor family member 6 (PAQR6) (Fig.4B and Table S3). The gene discussed is TNF; the disease is rheumatoid arthritis.