In addition, KEGG enrichment analysis showed that target genes of differential miRNAs between N-RA and HC group were mainly involved in VEGF signaling pathway, natural killer cell mediated cytotoxicity, leukocyte endothelial migration, N-glycan biosynthesis, sphingolipid metabolism, and antigen processing presentation (Fig. 6A). This evidence concerns the gene VEGFA and rheumatoid arthritis.