Recent studies have shown that hsa-miR-218-5p regulates the proliferation, apoptosis, autophagy and oxidative stress of rheumatoid arthritis synovial fibroblasts by targeting Kruppel like factor 9 (KLF9) and activating JAK2/STAT3 signaling pathway (Chen et al., 2021). The gene discussed is STAT3; the disease is rheumatoid arthritis.