While the expression levels of GRB7, MIEN1, ERBB2 and FBXL20 were considerably greater in tumour tissues than in normal tissues (p < 0.001 or p < 0.01), the expression levels of MED1 and CDK12 were significantly lower in tumour tissues than in normal tissues (p < 0.001). The gene discussed is CDK12; the disease is neoplasm.