One of the reproducible changes observed by mass‐spectrometry was an almost two‐fold increase of CD63 in the EVs produced by CD9 KO cells (and cells deficient in both CD9 and CD81) which was consistent with the western‐blot analyses showing higher CD63 enrichment in EVs in the absence of CD9, and similar to what was observed in the EVs released by CD9 KO melanoma cells (Suárez et al., 2021). The gene discussed is CD63; the disease is melanoma.