The gastric pH can be also affected by pathogens such as H. pylori when spreading from the antrum mucosa to the corpus and inducing atrophy, hypergastrinemia, or gastric adenocarcinoma.[46] Therefore, further work on developing MPS platforms which offer functionally linked antrum and corpus regions would help us comprehensively understand chronic H. pylori pathogenesis involving entrance, penetration, and cagA translocation of H. pylori in the pH gradient environment and investigate potential pharmacological approaches to gastric acid suppression for the treatment of acid‐related disorders. This evidence concerns the gene S100A8 and gastric adenocarcinoma.