Decreased Mic60 expression might slow cancer cell proliferation but enhance inflammation, cell quiescence, mitochondrial dynamics, cancer cell invasion, and metastasis through several mitochondrial retrograde signaling pathways, such as ROS, ATP, the type I interferon/senescence-associated secretory phenotype transcriptional signature, and the GCN2-ISR pathway [25]. The gene discussed is EIF2AK4; the disease is cancer.