JAK1 and Insulin resistance: Another new study also found enhanced serous IL-22 triggered IL-22R1/Janus kinase 1 (JAK1) /STAT3 signaling pathway in islets, which improved insulin resistance in PCOS rats [29].In addition, Park et al. set a cohort of transgenic mice IL-22TG6 with serous IL-22 at a moderate level (~ 600 pg/ml) to mimic the treatment of IL-22 [82].