Data from large-scale clinical trials have consistently shown that the beneficial effects of novel glucose-lowering drugs, such as sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA), extend far beyond glycemic control, reducing important cardiovascular and renal endpoints in populations with T2D [126–128]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.