In contrast to the results in HGSOC and human bladder cancer, ADNP functioned as a WNT repressor and exerted its anti-tumor impact on invasion, migration, and proliferation of colon adenocarcinoma (COAD) with an improved prognosis [10], which was consistent with the research in triple-negative breast cancer (TNBC) [11] and glioblastoma multiforme (GBM) [12]. Here, ADNP is linked to colon adenocarcinoma.