SALL4 and cancer: In accordance with previous studies, we revealed that SALL4 knockdown by si-SALL4-B or knockout by CRISPR/Csa9 decreased, while SALL4 overexpression by P-SALL4-B increased the levels of VEGF-A, B, and C, which indicates that SALL4/VEGF axis may be a common regulatory mechanism for cancer angiogenesis.