Consistent with the binding of SALL4 to VEGF family gene promoters in the MGC-803 gastric cancer cells transfected with P-SALL4, H3–K79 di-methylation and H3–K4 trimethylation were detected and increased in these cells as compared with control vector group (Fig. 4D-F). This evidence concerns the gene SALL4 and gastric cancer.