MiR-200c directly targets 3′ UTRs of IL-6, IL-8, interferon-related developmental regulator 1 (Ifrd1), and chemokine (C-C motif) ligand 5 (CCL-5), and downregulated their expression in human periodontal ligament, gingival fibroblasts, and the periodontium of periodontitis rats [40]. This evidence concerns the gene CXCL8 and periodontitis.