Allergens fairly rapidly influence IgE levels as demonstrated by the surges in IgE observed during aeroallergen seasons in allergic rhinitis patients and rapid reduction at the end of the exposure; ETI improves mucociliary clearance, and reduces fungal, Pseudomonal and other bacteria related burden, thereby reducing IL-4/IL-13 production and subsequently IgE levels. This evidence concerns the gene IGHE and allergic rhinitis.