Besides, exosomal circ-BTG2 or circ_0004658 secreted from RBP-J overexpressed-macrophages inhibited glioma or HCC progression by regulating miR-25-3p/PTEN or miR-499b-5p/JAM3 pathway, respectively [60, 61]. This evidence concerns the gene RBPJ and hepatocellular carcinoma.