In this study, we firstly found that hsa_circ_000200 acts as a ceRNA for miR-4659a/b-3p and competitively bind miR-4659a/b-3p with HBEGF, thereby inhibiting the activity of miR-4659a/b-3p and enhancing the expression of HBEGF, TGF-β and P-smad, which in turn played a role in promoting GC progression. Here, HBEGF is linked to gastric cancer.