The main neuropathological features of AD are neuritic plaques generated by extracellular β-amyloid (Aβ) deposition, neurofibrillary tangles formed by intracellular accumulation of hyperphosphorylated tau (p-Tau), and neuroinflammation, neuron and synapse loss, as well as astroglial proliferation [5]. This evidence concerns the gene MAPT and Alzheimer disease.