APP and cerebral amyloid angiopathy: Moreover, in the wild-type (Wt) mice parabiosis with APPswe/PS1dE9 (APP/PS1) transgenic (Tg) mice or transplanting bone marrow cells (BMCs) from APP/PS1 Tg mice, the plasma Aβ1-42 levels were significantly increased and plasma Aβ1-42 entered into Wt mice brain to form cerebral amyloid angiopathy (CAA) and Aβ plaques similar to Tg mice [38, 39].