Previous studies have reported that PARP-1 chronic activation, which occurs in many demyelinating disorders, causes neuronal death, axonal degeneration, and impairment of essential myelin proteins (e.g., myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), myelin-associated glycoprotein (MAG)) [14]. Here, PARP1 is linked to demyelinating disease.