Activation of pro-inflammatory pathways in the brain, including IL-6 pathway, TNF-α, IL-17A, and MIF comprises a potential point of convergence between chronic neuroinflammation and neurodegeneration in many brain diseases such as AD and MS, so it is rational to hypothesize that the elevation of these cytokines contributes to demyelination in MLD [30–32]. This evidence concerns the gene MIF and metachromatic leukodystrophy.