IL17A and melanoma: To further validate the link between IL-17 signaling GES (defined according to Kyoto Encyclopedia of Genes and Genomes (KEGG) hsa04657) and the MAPK pathway, we analyzed data from the largest available melanoma dataset from the Cancer Genome Atlas (TCGA) Skin Cutaneous Melanoma (TCGA-SKCM) cohort and found a significant association between IL-17 GES and the MAPK mutational state (Fig. 1d).