Both IL-17 and TH17 cell differentiation GES were among the most significantly over-represented pathways in MAPK-mutated (n = 77 BRAF hotspot-mutant, n = 42 NRAS hotspot-mutant, n = 1 NF1-mutant) melanomas compared to triple-WT melanomas (n = 36) (Extended Data Fig. 1b). This evidence concerns the gene NF1 and melanoma.