Here we report the primary analysis of GLOW, a global, randomized, double-blind, phase 3 study, which evaluated the efficacy and safety of first-line treatment with zolbetuximab plus CAPOX compared to placebo plus CAPOX in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or mG/GEJ adenocarcinoma. This evidence concerns the gene ERBB2 and gastroesophageal junction adenocarcinoma.