Evidence suggested that p300 mediates pulmonary fibrosis in ATII cells, and we next investigated the molecular mechanism underlying this relationship by performing RNA-sequencing (RNA-seq) analysis of murine primary ATII cells isolated from the lungs of four groups: phosphate-buffered saline (PBS)-treated Spc-p300f/f mice (Con), BLM-treated Spc-p300f/f mice (BLM), PBS-treated Spc-p300d/d mice (KO), and BLM-treated Spc-p300d/d mice (KOBLM) (Fig. 2a and Supplementary Fig. 5a). This evidence concerns the gene SFTPC and Bloom syndrome.