To further verify the ATII cell-specific role of p300 in the progression of lung fibrosis, inducible Ccsp-TGF-β1-TG mice were bred with Spc-p300f/f mice to generate a mouse model with inducible ATII cell-specific p300 gene deletion and TGF-β1 overexpression. Here, SFTPC is linked to pulmonary fibrosis.