PIK3CA and gastric cancer: The above findings indicate that SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating Zn2+-dependent CK2-mediated MAPK/ERK and PI3K/AKT pathways, while c-Myc, as a major downstream effector of these two pathways, directly transcriptionally regulates SLC39A10, forming a vicious feedback loop and then accelerating the malignant progression of gastric cancer.