The results indicated that SLC39A10 overexpression led to a significant increase in the intracellular Zn2+ concentration in the cytoplasm of cancer cells, and there is a study demonstrating that dysregulated Zn2+ homeostasis can induce the activation of some major signaling pathways, including the MAPK/ERK and PI3K/AKT pathways, which play extremely important roles in gastric tumorigenesis5,48,49. This evidence concerns the gene PIK3CA and cancer.