Furthermore, CCAR2 functions as a coactivator of PROX1 and MACC114,95, which are reported to promote CRC progression and metastasis, suggesting that CCAR2 plays a key role in CRC progression not only by enhancing LEF1-β-catenin-mediated transcription but also by amplifying Wnt/β-catenin signaling via activating Wnt/β-catenin-inducible TFs. The gene discussed is PROX1; the disease is colorectal carcinoma.