This could be attributed to the presence of an unrealistically high number of AP variants in the Platinum Genomes dataset, ~1.2 million AP variants per sample in contrast to ~5000 AP variants per sample for the ICGC/TCGA Pan-Cancer Analysis of Whole Genome Consortium24, which may have allowed other methods to leniently predict as many variants as possible, thereby overly inflating precision. Here, DHCR7-DT is linked to cancer.