Moreover, Thrap3 expression was upregulated in NAFLD and showed a significant tendency to increase with the increase in the NAFLD activity score (NAS) in the liver of nonalcoholic fatty liver (NAFL) patients (GEO accession GSE135251 and GSE130970)14–16 (Fig. 1d, e, Supplementary Fig. 1a). The gene discussed is THRAP3; the disease is non-alcoholic fatty liver.