Pediatric-type diffuse high grade glioma are classified into four groups (i) Diffuse midline glioma (DMG) H3 K27-altered, (ii) Diffuse hemispheric glioma (DHG) H3 G34-mutant, (iii) Diffuse pediatric-type HGG, H3-wildtype and IDH-wildtype, and (iv) Infant-type hemispheric glioma, typically with receptor tyrosine kinase (RTK) fusions [20]. This evidence concerns the gene IDH1 and central nervous system cancer.