The cohort included 64 H3K27M-mutant gliomas (35 females and 29 males) that had point mutations in FGFR1. 72% of these were N546K mutations and 28% were K656E, both occurring in the intracellular protein kinase domain of FGFR1 (Fig. 4). The gene discussed is FGFR1; the disease is glioma.