TRIP6 and colon adenocarcinoma: We compared the gene expression levels between normal and tumor tissues of COAD patients from TCGA and found that OXSM was significantly downregulated (p = 5.20 × 10–9), while TRIP6 (p = 5.00 × 10–12), MYH3 (p = 6.70 × 10–3), and MYH4 (p = 6.41 × 10–7) were upregulated in COAD tissues (Fig. 3e,f).