These data indicate that both macrophages and epithelial cells are sources of NLRP3-regulated IL-18 in EoE.  Further, we performed anti-MBP tissue immunostaining to detect esophageal eosinophilia, including intraepithelial eosinophils (Fig. 1c, i–ii). This evidence concerns the gene IL18 and eosinophilic esophagitis.