IL18 and eosinophilic esophagitis: Similarly, we also observed the effect of the NLRP3 downstream caspase1 inhibitor Belnacasan (VX-765) on A. fumigatus-induced experimental EoE. We found markedly reduced anti-caspase1 and anti-IL-18 expression in F4/80+ macrophages and epithelial cells in A. fumigatus-challenged mice treated with VX-765 compared with A. fumigatus-challenged mice given saline (Fig. 7c, d, i–ii).