The analysis detected anti-cytokeratin immunofluorescence stain epithelial cells show very few anti-cytokeratin+ NLRP3+ cells, anti-NLRP3+CD163+ macrophages, anti-NLRP3+caspase1+ cells, and anti-NLRP3+IL-18+ in normal patient biopsies (Fig. 6a–d, i) compared to induced expression of anti-cytokeratin+ NLRP3+ cells, anti-NLRP3+CD163+ macrophages, anti-NLRP3+caspase1+ cells, and anti-NLRP3+IL-18+ in the biopsies of active human EoE (Fig. 6a–d, ii). Here, IL18 is linked to eosinophilic esophagitis.