We have shown that both Aspergillus and corn extract challenge induce NLRP3 and caspase1 in esophageal epithelial cells and accumulated inflammatory macrophages in murine models of EoE these findings are consistent with the reports that indicates NLRP3 and caspase1 activation induces IL-1848,49. Here, NLRP3 is linked to eosinophilic esophagitis.