We presented sufficient evidence in establishing the critical role for IL-18 in the onset of EoE and show that pretreatment with NLRP3 and caspase1 inhibitors like MCC950, BHB, and VX-765 protects both food allergen- and aeroallergen-induced EoE pathogenesis in EoE experimental model. Here, IL18 is linked to eosinophilic esophagitis.