IL4R and eosinophilic esophagitis: The induction of allergen-induced cytokines like IL-5, IL-13, IL-18, and IL-33 are implicated in the pathogenesis of EoE2,15–17; however, clinical trials testing several cytokine neutralizers including anti-IL-5, anti-IL-13, and anti-IL-4R have not yet provided satisfactory results in improving EoE.