Therefore, in the study reported here, we examined the temporal relations and longitudinal associations of (i) BMI and cardiometabolic risk scores (CRS) calculated by insulin, glucose, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), waist circumference (WC), and blood pressure; (ii) BMI and obesity‐related proteins scores (OPS) calculated by adiponectin (ADP), soluble leptin receptor (sOB-R), resistin (RETN), IGF-binding protein-3 (IGFBP-3) and C-reactive protein (CRP); (iii) CRS and OPS among healthy women in a breast cancer screening cohort. The gene discussed is IGFBP3; the disease is obesity due to melanocortin 4 receptor deficiency.