IL1R1 and neoplasm: Consistently, iMDK could rescue the SC-CM-induced tumor metastasis, and IL-1RA could abolish malignant CAF phenotype induced by SC-CM (Fig. 7i–l and Supplementary Fig. S9m, n, G3 vs G2; G6 vs G5; Supplementary Fig. S9o–t, IL-1RA without SC-CM (G4) or CAF-CM (G5) were used as negative controls).