Motif discovery analysis using the MEME (Multiple Em for Motif Elicitation) (Bailey et al, 2015) algorithm revealed motif enrichment for IRF4 binding (ISRE), a TF critical for MM proliferation and/or survival (Shaffer et al, 2008), and the anticipated GR-responsive element (GRE) in GR-binding sites (Fig 1B). This evidence concerns the gene NR3C1 and Miyoshi myopathy.