Despite the large number of GR-binding sites on the genome, only a small number of genes were deregulated in response to Dex (982 up-regulated, 3.2%; 649 down-regulated, 2.1%; abs [log2fold change] > 0.6 and FDR < 0.05) in myeloma cells including well-known ubiquitous GR-responsive genes like TSC22D3 (alias GILZ), FKBP5, and cell-specific genes like BCL2L11 (alias BIM), an essential gene for Dex-induced death in MM.1S, and CXCR4, the chemokine receptor gene known to be associated with MM progression and poor prognosis (Fig 1F). The gene discussed is CXCR4; the disease is plasma cell myeloma.