The relative generalized hypermethylation of NF-κB active tumor genomes (Fig. 6A) is consistent with the predominance of spontaneous deamination of 5-methylcytosine as a mutagenetic process in NF-κB active tumors (54% vs. 27% in NF-κB inactive tumors, Fig. 4). The gene discussed is NFKB1; the disease is neoplasm.