To determine the role of macrophage specific NFATc3 on BLM-induced pulmonary fibrosis, we delivered 5 × 105 NFATc3+/- or NFATc3+/+ BMDM into the trachea of anesthetized recipient mice (NFATc3+/+ or NFATc3+/-) that were pre-treated with clodronate liposomes to deplete lung resident macrophage population as described previously (Fig. 5A) [21]. The gene discussed is NFATC3; the disease is pulmonary fibrosis.