In light of the timing of the PVL increase observed in reactivating cells (S7A Fig), it is likely that terms which showed increased expression late during reactivation, such as FSCN-1, VCAM-1, SDC-1, CCL22 and collagen had little impact upon the infection process in ex vivo patient samples; their upregulation was not necessary for the transfer of virions into target cells. The gene discussed is CCL22; the disease is infection.