Compared with noninitiators at baseline, CGRP mAb initiators included a higher proportion of women and persons who lived in urban areas, never smoked, were diagnosed with chronic migraine, had depression or were immunocompromised, and were prescribed triptans and migraine prophylaxis, such as anticonvulsants, β-blockers, tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors, and neurotoxins. This evidence concerns the gene CALCA and major depressive disorder.