In addition to well-known cancer-gene associations, we also identified that P/LP variants in BRCA1 (OR, 5.47; 95% CI, 1.42-17.17; P = .008) and FANCI (OR, 5.53; 95% CI, 1.03-19.47; P = .02) were associated with endometrial cancer. This evidence concerns the gene BRCA1 and endometrial cancer.