BRCA1 and cancer: Moreover, prophylactic removal of both ovaries and fallopian tubes (salpingo-oophorectomy) and/or the uterus (hysterectomy) in BRCA1/2 carriers is recognized as the most effective method for decreasing ovarian and endometrial cancer risk.29 Despite the substantial clinical relevance of germline findings in gynecologic cancer for therapeutic decision-making, genetic counseling, and intervention, current clinical guidelines only recommend germline testing for selected patients based on pathologic features of the tumor, onset age, and family history of cancer.