Moreover, prophylactic removal of both ovaries and fallopian tubes (salpingo-oophorectomy) and/or the uterus (hysterectomy) in BRCA1/2 carriers is recognized as the most effective method for decreasing ovarian and endometrial cancer risk.29 Despite the substantial clinical relevance of germline findings in gynecologic cancer for therapeutic decision-making, genetic counseling, and intervention, current clinical guidelines only recommend germline testing for selected patients based on pathologic features of the tumor, onset age, and family history of cancer. This evidence concerns the gene BRCA1 and female reproductive organ cancer.