CD44 also has several variants that are considered markers of CSCs.29,30 Traditionally, CSCs present in the tumor are positive for CD44, which is considered a CRC stem cell marker, and these cells are resistant to chemotherapeutic agents.31 It is believed that these stem cells survive and rebuild their original population after chemotherapeutic agent stimulation, exacerbating resistance to chemotherapeutic agents.32 CD44+ve cells have been reported to be chemotherapy-resistant as CSCs, but there are no reports on the unique CD44-ve cells that appear transiently after this chemotherapy. Here, CD44 is linked to neoplasm.