CD44 has been proposed as an important cancer stem cell marker in several cancers.14,15 CD44 is a cell surface glycoprotein that plays roles in the adhesion of the cytoskeleton to the extracellular matrix, cell–cell interactions, and cell migration.15-17 CD44 knockdown has been reported to prevent tumor formation and clonogenesis.18 The ability of CD44+ve/CD24+ve cells to differentiate into the enterocyte, enteroendocrine, and goblet cell lineages in vitro also has been established.19 CD44 overexpression has been linked to high cancer aggressiveness and resistance.20 This evidence concerns the gene CD44 and neoplasm.