When the young Mpv17 mutant mice that were free of glomerular disease were treated with nephrotoxic serum (NTS), they developed aggravated glomerular podocyte injury, accompanied by an increase of mitochondrial ROS and associated damage in the podocytes, suggesting that MPV17 functions to maintain mitochondrial homeostasis and prevents oxidative stress in podocytes under stresses [25]. Here, MPV17 is linked to glomerular disorder.