AKT1 and cancer: In addition to the METTL14/miR-99a-5p/TRIB2 axis, TRIB2 activates HDAC2 and inhibits HDAC2 (Ser394) phosphorylation through the Akt/mTOR/S6K1 signal pathway in ESCC, thus inhibiting cancer stemness and improving radiation resistance of ESCC cells [77].