Radiation resistant cell lines were generated by irradiating C666-1 and HONE1 cell lines of nasopharyngeal carcinoma, and a comparison of their respective FTO expression levels revealed that FTO was expressed at higher levels in the radiation resistant cell lines, i.e., FTO indeed had a close relationship with the cell radiation resistance of nasopharyngeal carcinoma. The gene discussed is FTO; the disease is nasopharyngeal carcinoma.