There were no significant differences in demographic and basal clinical characteristics including age, gender, renal function (creatinine, blood urea nitrogen [BUN]), myocardial enzymonram (myoglobin, creatine kinase [CK]‐MB, lactate dehydrogenase [LDH]), hematology (white blood cells [WBC], hemoglobin [HBG], platelets [PLT]), cardiac function index (brain natriuretic peptide [BNP]), and the incidence of sinus bradycardia and II°II atrioventricular block (AVB) between the three groups (all p > .5), indicating that the three methods evaluated were all safe. The gene discussed is NPPB; the disease is atrioventricular block.