In animal models, genetic depletion of GC‐A (Lopez et al., 1995; Oliver et al., 1997), ANP (John et al., 1995; John et al., 1996) or BNP (Holditch et al., 2015) leads to hypertension, cardiac hypertrophy/fibrosis and organ damage, demonstrating the importance of GC‐A activation in cardiovascular and renal homeostasis. This evidence concerns the gene GCA and Hypertension.